Ronneil Aviles presented at the Stem Cell Institute Journal club on March 27th 2009. Ronneil is currently a senior student majoring in Microbiology. He chose a paper "Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1" which was published in recent Science. This paper described that the gene encoding the basic helix-loop-helix protein HES1 is required for quiescence to be reversible, because HES1 prevented both premature senescence and inappropriate differentiation in quiescent fibroblasts. In myogenesis HES1 suppresses MyoD activity and maintains quiescent status of myoblasts. Therefore, quiescent muscle stem cells (satellite cells) may be regulated by MyoD inhibitors such as HES1.
No comments:
Post a Comment